I have a problem with all those who say the devil makes us sick, God wants us to stay sick, etc.
The Devil wants you to suffer the most.. God temporarily allows it and it is not for everyone,
1 Peter 1=6 Wherein ye greatly rejoice, though now for a season, if need be, ye are in heaviness through manifold temptations:
The faith is an ongoing battle,.. against wicked persons, demons, sicknesses, false accusers, pits, etc., and God can help us to overcome all of it, and he does for me.
Revelation 12-9 And the great dragon was cast out, that old serpent, called the Devil, and Satan, which deceiveth the whole world: he was cast out into the earth, and his angels were cast out with him.
Liberals, Democrats, John 8 -44 Ye are of your father the devil, and the lusts of your father ye will do. He was a murderer from the beginning, and abode not in the truth, because there is no truth in him. When he speaketh a lie, he speaketh of his own: for he is a liar, and the father of it.
1 Corinthians 10-21 Ye cannot drink the cup of the Lord, and the cup of devils: ye cannot be partakers of the Lord’s table, and of the table of devils.
James 3-15 This wisdom descendeth not from above, but is earthly, sensual, devilish.
James 4-7 Submit yourselves therefore to God. Resist the devil, and he will flee from you.
1 Peter 5-8 Be sober, be vigilant; because your adversary the devil, as a roaring lion, walketh about, seeking whom he may devour:
1 John 3-8 He that committeth sin is of the devil; for the devil sinneth from the beginning. For this purpose the Son of God was manifested, that he might destroy the works of the devil.
1 Timothy 4-1 Now the Spirit speaketh expressly, that in the latter times some shall depart from the faith, giving heed to seducing spirits, and doctrines of devils;
2 Timothy 2=26 And that they may recover themselves out of the snare of the devil, who are taken captive by him at his will.
Mark 16 -17 And these signs shall follow them that believe; In my name shall they cast out devils;
Acts 10-38 How God anointed Jesus of Nazareth with the Holy Ghost and with power: who went about doing good, and healing all that were oppressed of the devil; for God was with him
Revelation 20 -2 And he laid hold on the dragon, that old serpent, which is the Devil, and Satan, and bound him a thousand years,10 And the devil that deceived them was cast into the lake of fire and brimstone, where the beast and the false prophet are, and shall be tormented day and night for ever and ever.
Some of the problems are our own stupidity.. such as cancer by eating processed meats, burnt food or diabetes by skipping meals, sugar excess , high cholesterol by eating fatty foods, and lack of exercise, being ignorant of what food is bad or good for us, plus over indulgence, sadly many persons are too lazy or fearful to go see a doctor when they need too as well. If you are over 45 years old you need to read all of this..
Salt and Potassium intakes on Heart health.
It is said that the evidence for sodium restriction is “vacuous, lacks depth, and in some cases lacks integrity.” Especially with respect to heart failure, there is a shockingly small amount of evidence. Sodium restrictions do help reduce water retention. Reducing one]s salt intake may reduce your chances of dying of heart disease, high blood pressure, stroke, or diabetes.
Do not be deceived! All Salt is salt and the they all all contain an equally high sodium chloride content The Agency for Healthcare Research and Quality examined the effects of both sodium and potassium intake on health. It reported this year that lower sodium intake “most likely reduces” blood pressure. But it also reported that increasing potassium intake most likely has the same effect, because consuming more potassium causes you to excrete more sodium in your urine. (Of course, excess potassium has its own risks — any major dietary changes should be discussed with a physician.)
Other systematic reviews find that an increased intake of fibre is associated with a lower risk of heart disease.There were no data that showed that salt restriction reduced mortality or cardiac disease; affected whether someone was admitted to the hospital; or influenced how long they had to stay if admitted and there is a risk of emphasizing salt avoidance at the expense of other — potentially more useful — diet measures for what is best
It is important to note that we also lack a strong evidence base from randomized controlled trials where potassium and fibre are concerned.
We could advise people to exercise regularly (which has an enormous evidence base) and to eat more healthfully overall. Both the Dietary Approaches to Stop Hypertension diet and the Mediterranean diet have been associated with lower rates of heart failure.
If you have hyperkalemia, you have too much potassium in your blood. The body needs a delicate balance of potassium to help the heart and other muscles work properly. But too much potassium in your blood can lead to dangerous, and possibly deadly, changes in heart rhythm. In some people, potassium can cause stomach upset, nausea, diarrhea, vomiting, or intestinal gas. Too much potassium is UNSAFE and can cause feelings of burning or tingling, generalized weakness, paralysis, mental confusion, low blood pressure, irregular heart rhythm, or death.
It is true, though, that potassium can help lower blood pressure. The Pritikin Eating Plan, full of foods that are naturally rich in potassium like potatoes, beans, yogurt, and many fruits and vegetables (these foods are also very low in salt), has been documented to significantly lower blood pressure and reduce the need for hypertension medications
Yes scientists have found that for most people, monosodium glutamate, or MSG, is a safe salt substitute. The seasoning Accent, on supermarket shelves nationwide, contains MSG. There is no evidence that consuming MSG in moderation has any long-lasting negative impact on health or longevity.
Potassium Citrate Side Effects
confusion, anxiety, feeling like you might pass out;
extreme thirst, increased urination;
muscle weakness or limp feeling;
numbness or tingly feeling in your hands or feet, or around your mouth;
severe stomach pain, ongoing diarrhea or vomiting;
black, bloody, or tarry stool
Limit high-potassium foods such as:
bananas. Avocados. Raisins. prunes and prune juice. oranges and orange Juice. tomatoes, tomato juice, and tomato sauce. Lentils. spinach.
Is no salt substitute safe?
Possibly, b ut Salt substitutes are not a healthful option for everyone. Most, salt substitutes (including Morton Salt Substitute, NoSalt and Nu-Salt) consist of potassium chloride, which tastes somewhat like sodium chloride (table salt) but does not raise blood pressure. “Lite” or “low-sodium” salts (such as LoSalt andMorton Lite Salt) are blends of sodium chloride and potassium chloride. . Many persons with kidney problems are unable to rid their bodies of excessive potassium, which could result in a deadly situation.
Ingredients for a Salt Substitute Recipe
1 tablespoon dried basil. 1 tablespoon dried thyme.1 tablespoon ground coriander. 2 teaspoons onion powder. 2 teaspoons dried parsley flakes.2 teaspoons ground cumin. 1 teaspoon garlic powder.1 teaspoon ground mustard. ALSO: cumin, cayenne, paprika, black pepper,oregano,lemon peel, rubbed sage.Rosemary. Nutmeg. Cardamon. Cinnamon. Chives.Dill. Mint Chives.
Spironolactone belongs to the class of medications known as diuretics (water pills). It is used to treat edema (fluid retention) that occurs with congestive heart failure, cirrhosis of the liver, and nephrotic syndrome. It is also used to treat high blood pressure and to diagnose and treat primary hyperaldosteronism (a condition where too much aldosterone is produced by the adrenal glands). Spironolactone works by making the body lose excess water and salt but reduces the loss of potassium from the body.
What’s Causing Abdominal Pain and Diarrhea?
Abdominal pain and diarrhea that occurs at the same time can be caused by a variety of factors.These can include for a start
- a viral infection such as the stomach flu,
- or an intestinal disease. medication
Frequent, constant, or severe abdominal pain and diarrhea may indicate a disease or a more serious medical issue. Diarrhea that gets progressively worse and is bloody can be also be a sign of a more serious issue.
Possible causes of abdominal pain and diarrhea include:
• viral gastroenteritis (stomach flu)
• bacterial gastroenteritis (food poisoning)
• food allergies
• irritable bowel syndrome — a common disorder affecting the digestive system
• lactose intolerance — the inability to digest lactose, a sugar found in milk and some other dairy
• fecal impaction
• intestinal obstruction
• West Nile virus
• parasites (like giardiasis, amebiasis, or hookworm)
• bacterial infection (for example, shigellosis or E. coli)
• drug allergies
• celiac disease
• stress and anxiety
Other causes of abdominal pain and diarrhea
Infections or diseases that affect the organs in your abdomen can also cause pain with diarrhea. Organs
in the abdomen include your:
Indigestion, the stomach flu, and food poisoning are now the most common causes of acute diarrhea and abdominal pain.
Drinking Coca-cola, or eating Apples, Applesauce, Cinnamon, Spearmint, peppermint, black tea, lemon balm, mint,
Apples are a very good supplement of dietary fiber that not only relieve stomach ache, but also keep the digestive system well maintained. In already suffering, the consumption of apple also prevents abdominal pain from aggravating.
Carbonated beverages not only help in getting rid of gas bubbles, but also eliminate stomach ache. Consuming caffeine-free or carbonated beverages, specifically cola, ginger ale and lemon-lime soda leads to burping that helps in driving out the gas from the stomach.
A burning sensation can happen due to a variety of conditions. And it doesn’t necessarily indicate a skin problem.
Treatments for Skin Burning Sensations
Dry brushing can significantly improve skin health.
1 It promotes circulation.
2 It exfoliates your skin.
3 Dry brushing activates the nervous system, which helps to improve muscle tone by stimulating muscle fibers. It also improves circulation, promoting the delivery of oxygen-rich blood to muscles to help with recovery and toning.
4 It improves kidney function.
5 It can reduce cellulite.
Using long sweeping motions, start brushing at your feet and move upwards. And always brush towards your heart to aid in circulation and follow the natural flow of lymph.
After you’ve brushed your whole body, it’s time for a shower. To get your blood flowing and really promote circulation, alternate the temperature between hot and cold. After showering, make sure you moisturize. Coconut oil is a great choice for clearing and hydrating your skin, especially after dry brushing. . Clean your brush every week with soap and water to keep it hygienic.
NOTE drinking Cinnamon is especially rich in chromium and one of the most recommended foods for diabetics due to its ability to lower blood sugar quickly. Other great foods for your blood sugar include: beans , legumes , vegetables like broccoli and carrots , and seaweed such as kelp and spirulina
There are two components in lemons that are definite benefits if you have diabetes : soluble fiber and vitamin C. High-fiber diets have been shown to reduce blood sugar. Soluble fiber can also help lower heart disease risk by helping to lower blood pressure and cholesterol and help with weight loss
Another study found that taking apple cider vinegar before bed helped moderate blood sugar upon waking up.??
Too many persons push natural alternatives for all types of unproven yet cures
Research now suggests no benefit for daily use of aspirin in healthy, older people. Taking a low-dose aspirin daily has no benefit in warding off dementia, disability or cardiovascular disease in healthy, older adults, and may instead increase their risk of serious and potentially life-threatening bleeding, according to a study’s results, published in The New England Journal of Medicine, September 2018
“Taking a low-dose aspirin every day has long been known to cut the chances of another heart attack, stroke or other heart problem in people who already have had one, but the risks aren’t worth it for most folks, major new research finds
A tested aspirin study for people with diabetes, who are more likely to develop or die from heart problems, and found that the modest benefit it gave was offset by a greater risk of serious bleeding Aspirin did not help prevent cancer as had been hoped. And fish oil supplements, also tested in the study of people with diabetes, failed to help. Also a Boston-led study gave aspirin or dummy pills to 12,546 people who were thought to have a moderate risk of suffering a heart attack or stroke within a decade because of other health issues.
After five years, 4 per cent of each group had suffered a heart problem — far fewer than expected, suggesting these people were actually at low risk, not moderate. Other medicines they were taking to lower blood pressure and cholesterol may have cut their heart risk so much that aspirin had little chance of helping more, said the study leader, Dr. J. Michael Gaziano of Brigham and Women’s Hospital. One per cent of aspirin takers had stomach or intestinal bleeding, mostly mild– twice as many as those on dummy pills. Aspirin users also had more nosebleeds, indigestion, reflux or belly pain
Doctors in Australia and the United States enrolled more than 19,000 healthy people – whites over the age of 70 and blacks and Hispanics aged 65 and older – in the study. None of the participants was known to suffer from heart disease, dementia or persistent physical disability at the time of enrollment.
Half of those enrolled took low-dose aspirin – 100 milligrams – daily, while the rest took a placebo each day for an average of 4.7 years.
The doctors found that taking a daily low-dose aspirin did not decrease the risk of heart attack or stroke among participants when compared with the placebo group. It also did not prolong “healthy independent living” – life free of dementia or persistent physical disability.
Remedies To Get Rid Of Ingrown Toenail Pain
Ingrown toenails can worsen with time and hence need to be treated soon. Not all Doctors will deal with it especially if you have diabetes
How To Get Rid Of Ingrown Toenail Pain
1. Essential Oil
a. Tea Tree Essential Oil
You Will Need
• 2-3 drops of tea tree oil
• Coconut or olive oil (optional)
1. Take a few drops of tea tree oil on your fingertips and apply it directly to the ingrown nail.
2. You can also mix a few drops of tea tree oil with a carrier oil if you have sensitive skin.
Do this twice daily.
Tea tree oil is a powerful antiseptic and can help in preventing further infection of the ingrown toenail. It also has antibacterial and antifungal properties that can inhibit bacterial and fungal growth on the infected toe nail
b. Peppermint Oil
You Will Need
2-3 drops of peppermint oil
1. Clean the skin around the affected area or soak your feet in water for some time.
2. Pat dry and apply a few drops of peppermint oil to the ingrown toenail and the skin around it.
You can do this twice daily.
The menthol in peppermint oil helps in soothing the pain, and its strong antimicrobial properties protect
the toenail from further infection
2. Baking Soda
You Will Need
• 1/2 teaspoon of baking soda
• A few drops of water
• Bandage or sanitary gauze
1. Mix baking soda with water to make a thick paste.
2. Apply this paste to the cleansed toenail and the skin around it.
3. Cover it with a sanitary gauze or bandage.
You can do this 1 to 2 times daily.
Baking soda has natural antiseptic and sanitizing properties that keep your toenail infection-free. It also has antibacterial and antifungal properties that can inhibit the growth of bacteria and fungi on the infected toenail
3. Epsom Salt
You Will Need
• 1-2 tablespoons of Epsom salt
• Warm water
1. Add one or two tablespoons of Epsom salt to a wide bucket filled with water.
2. Soak your legs in it for 15 to 20 minutes.
You must do this 2 to 3 times daily.
Epsom salt has high magnesium content that helps fight inflammation and provides relief from the pain and swelling in the affected area .
4. Coconut Oil
You Will Need
Virgin coconut oil
Take a generous amount of virgin coconut oil and apply it to the ingrown toenail and the skin
Apply coconut oil twice daily.
Coconut oil has a wide range of medicinal benefits due to the presence of certain medium-chain fatty acids like lauric and caprylic acid. These fatty acids impart antifungal, analgesic, and anti-inflammatory properties to coconut oil, which can help in getting rid of the ingrown toenail and the pain
5. Apple Cider Vinegar
You Will Need
• Apple cider vinegar
• Cotton balls
1. Take a cotton ball and dip it in some apple cider vinegar.
2. Apply the soaked cotton ball directly to your infected toenail.
You must follow this procedure twice daily.
Apple cider vinegar can be your best bet to get rid of ingrown toenails. Its powerful anti-inflammatory properties can help reduce the pain and inflammation, and its antimicrobial properties can protect the ingrown toenail from bacterial or fungal infections
You Will Need
• 2-3 cloves of crushed garlic
• Bandage or sanitary gauze
1. Crush the garlic cloves and apply it on and around the infected toenail.
2. Cover it with a bandage or sanitary gauze and leave it on overnight.
You must do this once daily before going to bed.
Garlic contains a component called allicin that exhibits antimicrobial properties, which can protect the ingrown toenail from further infection and damage. Garlic also has anti-inflammatory properties that can help in speeding up the recovery
7. Hydrogen Peroxide
You Will Need
• 1/2 cup of 3% hydrogen peroxide
• Warm water
1. Pour half a cup of 3% hydrogen peroxide in a wide bucket filled with warm water.
2. Soak your feet in this for 15 to 20 minutes.
Do this 2 to 3 times daily.
Hydrogen peroxide is a natural disinfectant that is commonly used to clean wounds to prevent infection. This is because it is antibacterial and antifungal. These properties make hydrogen peroxide a great option for the treatment of ingrown nails
You Will Need
• 1 teaspoon of turmeric
1. Take a teaspoon of turmeric powder and add enough water to it to make a fine paste.
2. Apply this paste to the affected toenail.
You can do this 2 to 3 times a day.
Turmeric contains curcumin that exhibits anti-inflammatory and antimicrobial properties. These healing and soothing properties can be helpful in getting rid of an ingrown toenail and the pain.
9. Lemon Juice
You Will Need
• 1 teaspoon of freshly squeezed lemon juice
• A bandage or sanitary gauze
1. Apply freshly squeezed lemon juice to the toenail.
2. Cover it using a sanitary gauze or bandage and leave it on overnight
You must do this once daily, preferably before going to bed.
The acidic nature of lemons can be quite effective in combating the growth of bacteria on an ingrown toenail . Lemons also possess mild antifungal properties that can provide protection from fungal infections as well .
You Will Need
• 1 tablespoon of Listerine
• 1 tablespoon of water
• Cotton balls
1. Take equal quantities of Listerine and water and mix well.
2. Dip a cotton ball in this solution and apply it to the ingrown toenail using downward strokes. Or pour the mixtrure in a spray bottle,
You can do this 2 to 3 times daily.
Listerine contains compounds like menthol, eucalyptol, and thymol, all of which posses soothing and anti-inflammatory properties that can help in relieving the pain associated with an ingrown toenail.
Listerine is also antifungal and antibacterial and hence prevents further infection in the area).
You Will Need
• Sliced onions
• A sanitary gauze or bandage
1. Take a piece of sliced onion and apply it directly to the ingrown toenail.
2. Cover it with a bandage or sanitary gauze and leave it on overnight.
You must do this once daily before going to bed.
Onions are one of the best remedies to get rid of ingrown toenails. They contain compounds like allicepin, which possesses antifungal activities, and can thus be used to inhibit fungal growth on the infected toenail . Onions also exhibit strong antibacterial and anti-inflammatory activities that can be used to prevent further infection in the area and provide instant relief from the pain and inflammation
In addition to trying out the above-mentioned remedies, you can also follow these tips to avoid ingrown toenails.
See your doctor if you have an ingrown toenail and you have diabetes or another condition that causes poor circulation, or you have a compromised immune system
• Always cut your nails straight, without curving the edges. Avoid cutting your nails too short.
• Wear comfortable shoes that fit you properly. Use a toe protector when required.
• In case of abnormally curved or thick toenails, you can opt for surgery to prevent them from becoming ingrown.
Despite these measures, if you are unable to fix your toenails, you need to visit your doctor immediately. An ingrown toenail can lead to complications and discomfort if not treated on time. You might have to see your doctor if:’
What is the recovery period for an ingrown toenail surgery?
The recovery period can last anywhere from 6 to 8 weeks.
What kinds of salt can cure an ingrown toenail? Salts such as Epsom salt, table salt, and baking soda can be quite effective in curing an ingrown toenail as they have antimicrobial and anti-inflammatory properties Toenails that have become thicker over time are a likely sign of aging, medical condition or a fungal infection. Learn what symptoms to look for and how to treat this condition. You can try a variety of
home-based methods to treat nail fungus:
• Clean the affected area with soap and water daily.
• Groom your nails regularly.
Soften your nails first by applying urea cream (Aluvea, Keralac) and wrapping your feet in bandages at night. Then wash off the urea cream and use a nail clipper and nail file to trim your nails.
• Apply an over-the-counter fungal treatment after you gently file your nails.
• Apply Vicks VapoRub on your toenail each day. This may help the infection subside. Vicks VapoRub did work completely in over a quarter of people with yellow toenails and helped cure some of the infection in over half
• Apply snake root extract to the toenail every third day for one month, twice a week in month two, and then just once a week in month three.
Do You Have Bad Kidneys
Your kidneys are bean-shaped organs that perform many important functions.
They’re in charge of filtering blood, removing waste through urine, producing hormones, balancing minerals and maintaining fluid balance.
There are many risk factors for kidney disease. The most common are uncontrolled diabetes and high blood pressure. Alcoholism, heart disease, hepatitis C virus and HIV infection are also causes
When the kidneys become damaged and are unable to function properly, fluid can build up in the body and waste can accumulate in the blood. However, avoiding or limiting certain foods in your diet may help decrease the accumulation of waste products in the blood, improve kidney function and prevent further damage
The Connection Between Diet and Kidney Disease
A kidney-friendly diet, or a “renal diet,” usually includes limiting sodium and potassium to 2,000 mg per day and limiting phosphorus to 1,000 mg per day.
Here are foods that you should likely avoid on a renal diet.
1. Dark-Colored Colas
In addition to the calories and sugar that colas provide, they also contain additives that contain phosphorus, especially dark-colored colas.
Avocados are often touted for their many nutritious qualities, including their heart-healthy fats, fiber and antioxidants.
Summary Avocados should be avoided on a renal diet due to their high potassium content. One cup of avocado provides nearly 37% of the 2,000 mg potassium restriction
4. Whole-Wheat Bread
Whole-wheat bread may be a more nutritious choice, mostly due to its higher fiber content. However, white bread is usually recommended over whole-wheat varieties for individuals with kidney disease. This is because of its phosphorus and potassium content. The more bran and whole grains in the bread,the higher the phosphorus and potassium contents.
5. Brown Rice
Like whole-wheat bread, brown rice is a whole grain that has a higher potassium and phosphorus content than its white rice counterpart.. White rice, bulgur, buckwheat and couscous are all good alternatives.
Bananas are known for their high potassium content.
Dairy products a natural source of phosphorus and potassium
However, when the kidneys are damaged, too much phosphorus consumption can cause a buildup of phosphorus in the blood. This can make your bones thin and weak over time and increase the risk of bone breakage or fracture Dairy alternatives .
8. Oranges and Orange Juice
Oranges and orange juice are high in potassium and should be limited on a renal diet. Try grapes, apples, cranberries or their juices instead.
9. Processed Meats
Processed meats have long been associated with chronic diseases and are generally considered unhealthy due to their content of preservatives and lack of nutrients Processed meats are meats that have been salted, dried, cured or canned. Some examples include hot dogs, bacon, pepperoni, jerky and sausage. Processed meats are high in salt and protein and should be consumed in moderation on a renal diet.
10. Pickles, and Relish
Pickles, processed olives and relish are all examples of cured or pickled foods. Usually, large amounts of salt are added during the curing or pickling process.However, even reduced-sodium options can still be high in sodium, so you will still want to watch your portions.
Apricots are rich in vitamin C, vitamin A and fiber.
They are also high in potassium. It’s best to avoid apricots, and most importantly dried apricots, on a renal diet.
12. Potatoes and Sweet Potatoes
Potatoes and sweet potatoes are potassium-rich vegetables.
Just one medium-sized baked potato (156 g) contains 610 mg of potassium, whereas one average-sized baked sweet potato (114 g) contains 541 mg of potassium
Potatoes that are soaked in a large pot of water for at least four hours before cooking are proven to have an even lower potassium content than those not soaked before cooking potatoes and sweet potatoes are high-potassium vegetables. Boiling or double cooking potatoes can decrease potassium by about 50%.
Tomatoes are another high-potassium fruit that may not fit the guidelines of a renal diet.. However, swapping tomato sauce for a roasted red pepper sauce can be equally delicious, all while providing less potassium per serving.
14. Packaged, Instant and Pre-Made Meals
Processed foods can be a major component of sodium in the diet. Examples include frozen pizza, microwaveable meals and instant noodles.
15. Swiss Chard, Spinach and Beet Greens
Swiss chard, spinach and beet greens are leafy green vegetables that contain high amounts of various
nutrients and minerals, including potassium. Although serving size becomes smaller when cooked, potassium content remains the same.
16. Dates, Raisins and Prunes
Nutrients are concentrated when fruits are dried. Therefore, the potassium content of dried fruit, including dates, prunes and raisins, is extremely high and should be avoided on a renal diet.
17. Pretzels, Chips and Crackers
Ready-to-eat snack foods like pretzels, chips and crackers tend to be lacking in nutrients and relatively high in salt.
If you have kidney disease, reducing your potassium, phosphorus and sodium intake can be an important aspect of managing the disease.
The high-sodium, high-potassium and high-phosphorus foods listed above are likely best limited or avoided.
Studies reveal role of red meat in gut bacteria, heart disease development
December 10, 2018, Cleveland Clinic Stan Hazen, MD, PhD, of Cleveland Clinic Credit: Cleveland Clinic
In concurrent studies, Cleveland Clinic researchers have uncovered new mechanisms that demonstrate why and how regularly eating red meat can increase the risk of heart disease, and the role gut bacteria play in that process.
“One of our most surprising findings was that a diet rich in red meat actually changed kidney function. We saw that the kidneys were being regulated by a chronic diet. This is something that, as far as I am aware, hasn’t been shown before,” Hazen told NBC News.
The research, led by Stanley Hazen, M.D., Ph.D., builds upon previous work showing TMAO (trimethylamine N-oxide) – a gut bacteria byproduct formed during digestion—can lead to the development of cardiovascular disease, including heart attacks and strokes. TMAO is produced when gut bacteria digest choline, lecithin and carnitine, nutrients that are abundant in animal products such as red meat and liver and other animal products.
In a new dietary intervention study published today in the European Heart Journal, the researchers found that a diet rich in red meat as the primary protein source significantly increases circulating TMAO levels, compared to diets with white meat or non-meat as protein sources. The study showed chronic red meat consumption enhanced the production of TMAO by gut microbes and reduced the kidneys’ efficiency of expelling it. Both enhanced production and reduced elimination caused by a red meat diet contribute to elevation in TMAO levels, which has been linked to the development of atherosclerosis and heart disease complications.
High levels of TMAO in the blood have been shown to be a powerful tool for predicting future heart attack, stroke and death risks, according to previous research initially spearheaded by Dr. Hazen and his team, and subsequently replicated around the world. TMAO testing is now in clinical use as a result. Dr. Hazen chairs the Department of Cellular and Molecular Medicine in Cleveland Clinic’s Lerner Research Institute and is co-section head of Preventive Cardiology & Cardiac Rehabilitation in the Miller Heart &Vascular Institute.
The study included 113 participants who sequentially (in random order) were provided complete meal plans prepared using either red meat, white meat or non-meat (mostly vegetarian) protein sources as 25 percent of their daily calories. All participants had a wash-out diet in between meal plans.
After one month of the red meat diet, the vast majority of study participants experienced an elevation in TMAO levels in blood and urine. On average, TMAO levels in the blood increased approximately 3-fold during the red meat diet, compared to the white meat or non-meat diets, with some patients showing over a 10-fold rise. Similar increases were observed in the urine. However, after patients stopped the red meat diet, TMAO levels in the blood and urine subsided over the following month.
The study also revealed the unanticipated finding that a participant’s chronic dietary choices impacted kidney function by changing the effectiveness of the kidneys to expel compounds. For example, while a red meat diet decreased TMAO excretion, the red meat diet increased the excretion efficiency of carnitine and other carnitine-derived metabolites.
“This is the first study of our knowledge to show that the kidneys can change how effectively they expel different compounds depending on the diet that one eats—other than salts and water,” said Dr. Hazen, who also directs Cleveland Clinic Center for Microbiome and Human Health. “We know lifestyle factors are critical for cardiovascular health, and these findings build upon our previous research on TMAO’s link with heart disease. They provide further evidence for how dietary interventions may be an effective treatment strategy to reduce TMAO levels and lower subsequent risk of heart disease.”
In another study, published today in the Journal of Clinical Investigation, Dr. Hazen and his research team revealed a potential new target for preventing cardiovascular disease by drilling deeper into a gut microbial pathway that converts carnitine into TMAO.
The researchers found that carnitine—a nutrient abundant in red meat and some energy drinks and supplements—is converted to TMAO in the gut through a two-step process facilitated by distinct gut bacteria. The team discovered that the first step is similar in both omnivores (meat eaters) and vegans/vegetarians. But in the second part, the formation of TMAO is significantly enhanced in omnivores. Researchers then went on to show that a daily carnitine supplement can induce TMAO production, even for vegans and vegetarians who continue eating their normal diets. Earlier this year, Dr. Hazen and his team published a study showing how researchers had designed a potential new class of drugs for prevention of heart disease and clotting risk by interrupting the microbial pathway by which choline is converted into TMAO.
Dr. Hazen’s team compared the impact of daily oral carnitine supplements on omnivores versus vegetarians/vegans. At baseline, vegan/vegetarians showed limited ability to produce TMAO from carnitine while omnivores rapidly produced TMAO. After one month of supplementation, both groups showed an increased capacity to produce TMAO.
An October article in the journal Nutrients reviewed the research in recent years on TMAO, saying “there is convincing evidence suggesting an association between TMAO and inflammation. Furthermore, in the last decade the studies suggesting an association between high plasma TMAO levels and risk for developing atherosclerosis have increased markedly. And eating a lot of red and processed meat probably increases your risk of bowel cancer.
Regular consumption of red meat can raise levels of a cardiovascular disease causing the =chemical organic compound – known as TMAO (trimethylamine N-oxide) – is produced in the gut during digestion. more than 10 times, suggests the study. It’s high levels have been associated with increasing the risk of strokes, heart attacks and premature death.
Stay tune for more…